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Our findings highlight the potential of simultaneously targeting GLP-1R, Y1-R, and Y2-R and provide evidence suggesting a significant role for Y1-R agonism in the control of food intake and glucoregulation

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In the SURMOUNT-5 trial, tirzepatide resulted in a mean weight loss of 20.2% at 72 weeks, with 80% of participants achieving at least 10% weight loss and nearly 50% reaching 20% or more

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