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L-cells in the upper small intestine demonstrate co-localization with gastric inhibitory peptide (GIP), and thus, bear some resemblance to neighboring K-cells, while L-cells in the lower small intestine show high levels of co-localization with PYY and CCK

Leachables are the subset of extractables that actually migrate into the drug product under normal storage and use conditions

These vary in the strength and consistency of supporting evidence, so it is useful to distinguish between the better-established findings and those representing a more preliminary evidence base

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The cell cycle inhibitor, CDKN2D/p19INK4d, and NFT molecular signatures significantly overlapped with the senescent neuron population (39)