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Pull the syringe plunger back slightly to draw in a small amount of air

This is not dramatic enough to cause clinical dehydration in most people

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As a GIP receptor agonist, tirzepatide enhances insulin secretion in a glucose-dependent manner, meaning it stimulates insulin release only when blood glucose levels are elevated, thereby reducing the risk of hypoglycemia

Those taking the drug had systolic blood pressures the pressure on blood vessels when the heart contracts that were from 7.4 to 10.0 millimeters of mercury lower than those of participants taking a placebo