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Therefore, we hypothesized that sertraline treatment in combination with RT would not only target the tumor by SHMT inhibition to enhance sensitivity of NSCLC tumors to radiation in vivo but may also release the brake on the immune system

Acyl-CoA synthetase long-chain family member 4 (ACSL4) converts free PUFAs into acyl-CoA derivatives (PUFA-CoAs), which are subsequently esterified into lysophosphatidylcholine acyltransferase 3 (LPCAT3) [12, 13]

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