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In Trial 8, one of the CV outcomes trials, 891 (56%) patients treated with semaglutide tablets were 65 years of age and over and 200 (13%) patients treated with semaglutide tablets were 75 years of age and over

In the apo-OsDHAR structure, the OG atom of Ser23 is 3.4 away from the SG atom of Cys20, which is an acceptable hydrogen bonding distance considering the rotational movement of the side chains of Ser23 and Cys20

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We then refined it by subcellular location

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