Exenatide and lixisenatide both have relatively short half-lives and are considered short-acting GLP-1 RAs
With spending projections expecting continued sharp increases, PBMs have an important role to play in shaping prescription patterns more aligned with medical evidence (including trial data, treatment guidelines, medical best practices, etc.) and comparative research rather than drug maker promotional agendas
The Congressional Budget Office (CBO) estimates that Medicare coverage alone would increase net federal spending by roughly $36 billion by 2034
Another study a meta-analysis and review of 78 trials involving more than 73,000 participants concluded that semaglutide was associated with an increased incidence of NAION but emphasized that evidence for a causal link remains inconclusive
[DOI] [PMC free article] [PubMed] [Google Scholar] 51.Herman R.J., Hayes M.R., Audrain-McGovern J., Ashare R.L., Schmidt H.D