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Safety checks in trials include monitoring side effects, lab tests, and other health indicators to ensure that no new or rare issues emerge

The preservation of full efficacy, despite lower potency, suggests that the compound effectively engages key activation-relevant residues within the receptor binding cavity, in agreement with predicted computational analyses

The primary endpoint is the time to the first occurrence of a composite primary outcome event, defined as a persistent eGFR decline (50% from baseline), reaching ESRD, renal death, or CV death

Patients also receive 30-minute monthly follow-ups that include side effect management, body composition analysis, meal prep, exercise coaching, and personalized treatment plans

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