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GSH is a tripeptide synthesized in the cell cytosol from the amino acids precursors: glutamate, cysteine, and glycine, by two ATP-requiring enzymes: glutamate-cysteine ligase (GCL) and GSH synthetase (GSS)

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10.1158/1541-7786.MCR-21-0702 59 FernandoS.WallaceE

Foods high in sulfur, such as garlic, onions, and cruciferous vegetables, as well as colorful fruits and vegetables rich in antioxidants, can help boost glutathione production

It is noteworthy that a study using a humanized liver ApoE 4/4 mouse model found that mice with the ApoE 4/4 genotype exhibited significantly lower plasma ApoE4 levels compared to those with the ApoE 2/3 genotype