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Effectively addressing sleep disturbances is essential for managing both conditions, as they can exacerbate depressive symptoms and accelerate diabetes progression

349 If the ulcers fail to show a 50% reduction after 4 weeks of appropriate management via conventional methods, several advanced therapies, including negative-pressure therapy, growth factor therapy, bioengineered tissue, acellular matrix tissue, stem cell therapy, hyperbaric oxygen therapy, and, most recently, topical oxygen therapy, can be considered

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Moreover, recruitment of this triple combination therapy regimen can reduce the incidence of inflammation and skin irritation induced by hydroquinone or retinoids (Gupta et al., 2006)