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and 4: strong generalized irregularity of the diameter of the blood vessels with severe atrophy of the optic disc, barely visible (extremely faint presentation) choroidal blood vessels (bright fundus background color)

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In contrast, as mentioned above in a follow-up nested casecontrol study from the Nurses Health Study, it was reported that a combination of a polymorphism in the MnSOD gene together with the Leu/Leu genotype in the GPx-1 gene, confers a significant increased risk of breast cancer (80)

Therefore, a still completely unknown mechanism of action, efficacy, and safety profile cannot be ignored. Translation: we dont actually know what this stuff does in your body, because nobody has properly studied it in your body