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Follow up study: influence of smoking

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However, it is worth noting these improvements may reflect the physiologic consequences of rapid weight loss rather than reversal of underlying disease mechanisms, and whether such changes would persist without definitive obesity treatment is unknown

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Pharmacokinetics of tirzepatide demonstrated dose proportionality over the wide dose range, with C max of 180 nM in individuals treated with one dose of 8 mg and a C max of 260 nM with 15 mg/week dose in the clinical study, exceeding the EC50 values for GIPR and GLP-1R activations by approximately 10,000-fold and 250-fold, respectively (63)