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Each dose level is maintained for at least four weeks before increasing

Villain explained that certain genotoxic impurity concerns that may have been purged through traditional SPPS can become more prominent in fragment-based processes

The cell viability was assessed by Hoechst staining of the nucleus (see Methods) and hence assessment of total cell numbers after 72 h of treatment, which is a good proxy for cell survival and cell growth upon prolonged compound exposure

(PubMed) USDA, FDA and ODS-NIH Database for the Iodine Content of Common Foods 3.0

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