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It increases the risk of numerous secondary diseases such as type 2 diabetes, high blood pressure, cardiovascular disease and certain types of cancer, as well as joint problems and mental illness

GLP-1 medications are contraindicated for patients with personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2 (MEN2)

Long-Term Treatment Considerations Both Retatrutide and Tirzepatide appear most effective as chronic treatments

Adjustments based on measured levels reduce risk and improve outcomes

But biology is individualsome people respond better to one mechanism than the other