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Some participants experienced increased aggression or agitation, but these were infrequent and comparable to placebo groups

Liu S, Gad M, Li C, et al

The results are inconclusive, but there are some promising results so far: In one small study with just 12 (healthy middle-aged non-smoker) subjects (taking either 500 or 1,000 mg per day liposomal glutathione for four weeks), there was a trend for increasing glutathione levels, although it only became significant in the 500 mg dose after two weeks, which was also the largest increase at 25%

Due to the lack of comprehensive studies on natural compounds, little is known about their dosing and side effect profiles

The redox couple between glutathione and ascorbic acid: a chemical and physiological perspective