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In Gram-positive bacilli, many studies on the putative physiological role of GGTs have ruled out their involvement in glutathione degradation for amino acid utilization, as these bacteria cannot synthesize glutathione (Fahey et al., 1978), although they can hydrolyze it under in vitro conditions (Minami et al., 2003b)

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73 In efforts to counter this limitation, a study group designed, synthesized, and screened 40 new NBDHEX analogs

Figure 6 presents a 3D surface plot illustrating the predicted solubility (x) of rivaroxaban as a function of temperature (T) and the mass fraction of dichloromethane (w) in a methanol mixture, as modeled by ADAGPR