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However, despite its small size (39 amino acids) and low effective dose, Exe4 has a short half-life, requiring frequent injections similar to other biologics

Other two open label studies, totaling 26 patients, revealed a positive effect of ALC in reducing neuropathic pain intensity

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Moreover, overexpression of cGAS in RA-FLSs enhanced both the proliferation of these cells and the expression of pro-inflammatory factors ( Sting1 +/ mice, which have a reduced expression of phosphorylated TBK1, showed a decreased severity of arthritis and improved histological changes compared to control mice ( Figure 2 )