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Patients with mild to moderate renal impairment generally do not require dose adjustment, but closer monitoring may be warranted, particularly for signs of gastrointestinal adverse effects that could lead to dehydration and worsening renal function

Conley RR, Ascher-Svanum H, Zhu B, Faries DE, Kinon BJ

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Woody and musk categories (excluding odorless) occupy the highest molecularweight regime (230240 Da), consistent with their roles as persistent base notes

Antipsychotic dosing in preclinical models is often unrepresentative of the clinical condition: a suggested solution based on in vivo occupancy