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Gpx4 deficiency does not affect the proliferation of regulatory T cells (Tregs), which may be related to increased production of thioredoxin-1 in Tregs, enhancing their tolerance to oxidative stress [83, 91]
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In addition, H2O2 may activate transcription by directly oxidising H2O2-responsive transcription factors via oxidation of thiols of cysteine residues in protein
