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The Multi-Log Dosing Window : A landmark study investigating Achilles tendon healing in rats demonstrated that the therapeutic benefit, measured by improved biomechanical strength and functional recovery, was statistically equivalent across doses spanning six orders of magnitude: from 10 micrograms per kilogram (mcg/kg) down to 10 picograms per kilogram (pg/kg) [4]

FE, fixed effect

2,3 Weight loss usually picks up as the dose increases over the following months

Mounjaro and other GLP-1s should be avoided or used only under close supervision by people with a history of pancreatitis, gallstones, medullary thyroid cancer or MEN2, severe kidney disease, a very low BMI or eating disorder, and during pregnancy or breastfeeding

Comparing to CagriSema, it better tolerated in all GI side effects except diarrhea