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Retatrutide , developed by Eli Lilly, is a novel triple agonist that simultaneously activates three receptors: GLP-1 (glucagon-like peptide-1) receptor reduces appetite and slows gastric emptying GIP (glucose-dependent insulinotropic polypeptide) receptor enhances insulin secretion

(2017) 313:L278l92

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These may include headaches, nausea, injection site reactions since its administered via a subcutaneous injection, water retention, and altered cortisol levels