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Peptides were pooled in 0.5 ml Protein LoBind tubes, dried almost to completion and resuspended in 20 l solvent (3% MeCN, 0.1% TFA) with 7 l analyzed by LCMS/MS

69,70 Recent evidence suggests a central nervous system component, as a modified exenatide with reduced brain penetration caused less vomiting in animal models while preserving glucose-lowering effects

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It enhances glucose-dependent insulin secretion, keeping blood sugar stable without the hypoglycemic crashes that drive cravings