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Endocrine reviews, 34(3), 309338

Always discuss your full medical history and any recent medication changes with your prescriber

[8] [20] Beyond nausea, patients commonly experience a constellation of gastrointestinal symptoms including: Vomiting (reported in 24% of semaglutide users) Diarrhea (affecting 30% of patients) Constipation (occurring in 24% of users) Abdominal pain or discomfort (experienced by 20% of patients) Bloating and excessive gas Acid reflux or heartburn Decreased appetite (which, while therapeutic, can feel uncomfortable) The severity of these symptoms typically ranges from mild to moderate, and most patients do not discontinue treatment due to nausea alone

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