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With a BMI of 27 or higher (overweight) who also have weight-related health conditions such as hypertension, type 2 diabetes, or dyslipidemia

But: Semaglutide if: You prefer a tried-and-tested therapy You have type 2 diabetes and desire dual gain You are cautious about newer drug side-effects Select Tirzepatide if: You desire maximal weight loss effect You experience ongoing hunger and cravings You are receptive to newer, dual-mechanism therapy Always see a licensed healthcare professional or obesity medicine specialist to decide on the proper therapy for your individual needs and medical history

Those are weeks you do not get back

A 2025 real-world safety comparison found the two drugs had distinct safety profiles, rather than one being safer overall

If you are unsure which size to use, ask your healthcare provider for advice