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Distribution of this acetyl-CoA between the oxidation in the TCA cycle and participation in ACh synthesis is regulated through limitation of the TCA cycle rate by the ThDP-dependent OGDH, and the non-coenzyme action of thiamine and derivatives on the other enzymes involved (221)

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DiMarchi, Optimization of peptide-based polyagonists for treatment of diabetes and obesity

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He acknowledged that the variants are genuine, but their individual influence is limited: "The genetic effects identified so far are real but they're small." What works better than any gene panel today is almost disappointingly simple