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J Ayurveda Integr Med 1(3):190 Chopra A, Saluja M, Tillu G, Venugopalan A, Narsimulu G, Handa R, Bichile L, Raut A, Sarmukaddam S, Patwardhan B (2012) Comparable efficacy of standardized Ayurveda formulation and hydroxychloroquine sulfate (HCQS) in the treatment of rheumatoid arthritis (RA): a randomized investigator-blind controlled study

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Once GSH is depleted, ROS and reactive nitrogen species escalate, leading to increased oxidative stress, mitochondrial dysfunction, and DNA damage