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GLP-1 receptor agonists can also be considered, though weight loss targets differ: guidelines recommend a 3% to 5% weight loss for lean patients instead of 10% or more for patients with obesity

14 However, in two studies that included participants not enrolled in the SURPASS and SURMOUNT studies, ie, a large number of individuals who switched from other GLP-1 RAs to tirzepatide, those who transitioned from semaglutide experienced greater weight loss with tirzepatide treatment

Bone turnover markers, plasma type 1 collagen cross-linked C-telopeptide (P-CTX), and plasma propeptide of type 1 procollagen (P-P1NP) were assessed from fasting blood samples

That idea became the foundation for the modern GLP-1 medication industry

W., Silva, C