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In the central nervous system particularly the hypothalamus, brainstem, and nucleus accumbens GLP-1R signaling reduces appetite and slows gastric emptying

"GLP-1 Weight Loss Drugs: Coverage Under Medicaid and Other Health Plans." Analysis showing 9 states cover GLP-1s for obesity under Medicaid as of March 2025

Let your doctor know if you are taking semaglutide or if you have any other risk factors of NAION

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Gastrointestinal side effects represent the most common adverse reactions to GLP-1 medications, with frequencies varying by agent but often affecting 20-40% of patients according to product information