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Research published in Ageing Research Reviews has explored the relationship between GHRH analogs, growth hormone secretion, and IGF-1 regulation, helping establish the physiological basis for their use in carefully selected patients (Merriam et al., 2003)

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86 In a series of pharmacological in vivo experiments, the effectivity of intradiscally injected GDF6 was tested based on the use of an applied posterior IVD puncture model in which the left facet joint between the fourth and fifth lumbar vertebrae was removed as well as the left small joints of L2/3, L3/4, and L4/5

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