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They all work by leveraging the body's own incretin system to improve glucose regulation, and most of them produce significant weight loss as a beneficial side effect, or in some cases, as the primary intended effect

GLP1 receptor agonists are prescription medications that mimic the effects of the hormone glucagonlike peptide1, which is naturally released by the body after eating

Treatment duration may vary from months to years depending on therapeutic goals and clinical response

The in vivo effects of AT-7687 were evaluated in obese cynomolgus monkeys, and when combined with the GLP-1 analogue liraglutide, AT-7687 enhances weight reduction induced by liraglutide and improves glycemic control and lipid metabolism (51)

Semaglutide reduced time to first revascularization vs placebo in the overall study