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Studies have reported that gastrointestinal disturbances such as nausea, vomiting, diarrhea, and constipation are common (incidence rate 44 %, 30 %, 24 %, and 24 %, respectively [31]) and often dose- and time-dependent in patients with overweight or obesity [41,44,45]

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*Correspondence: Fangfang Zhou, [email protected] These authors have contributed equally to this work This article was submitted to Molecular Innate Immunity, a section of the journal Frontiers in Immunology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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Click counting is widely considered unsafe, since it can easily lead to taking too much or too little medicine for your needs