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Preclinical studies demonstrated that tirzepatide reduced glucose levels during intraperitoneal glucose tolerance tests in wild-type and single incretin receptor-deficient mice to levels comparable to those observed for the GLP-1R agonist semaglutide in Gipr / mice and the DPP-4-resistant analog [d-Ala 2 ]GIP in Glp1r / mice, indicating that the co-agonist is active at both receptors in vivo [84]

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Bien que la posologie varie dune tude lautre, voici un aperu de lutilisation et de la dose pour chaque forme