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A landmark JAMA Internal Medicine meta-analysis of 76 randomized clinical trials found that GLP-1 receptor agonists as a class were associated with increased risks of cholelithiasis (relative risk 1.27), cholecystitis (relative risk 1.36), and biliary disease broadly (relative risk 1.55)

PlexusDx Precision Peptide Genetic Test identifies variations in GLP1R, GIPR, FTO, and MC4R genes that influence medication responsiveness and metabolic predisposition

Healthcare providers have also observed this in their patients, leading to further investigations

In the study, 32 patients between the ages of 34 and 54 and without diabetes were given 1,000 milligrams of Acetyl-L-Carnitine twice daily for 6 months

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