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DATS inhibited bacterial lipopolysaccharide (LPS)-induced macrophage activation by limiting LPS binding to toll-like receptor 4 (TLR4) and blocking the upregulation of TLR4 and TLR4-associated molecule MyoD88 expression (37)

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Mercaptoacetic acid was dimerized in the presence of trifluoroacetic acid and acetone and then reduced with lithium aluminum hydride into the linker 2,2-(propane-2,2-diylbis(sulfanediyl))diacetic acid (synthetic strategy: Supplementary Fig