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Using these alignments, a consensus sequence was designed to represent the most common amino acid at each position across the aligned sequences

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The implication for practice is that incretin therapy is not a substitute for ApoB-lowering therapy in established ASCVD but is complementary: aggressive ApoB lowering addresses the lipid driver of atherogenesis, while incretin therapy addresses residual inflammatory, vascular, and metabolic risk

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This hormone degrades more slowly than the human form of GLP-1, lasting for hours instead of minutes