Before comparing which option may lead to more weight loss, it helps to look at how these medications are grouped by active ingredient, brand, and approved uses
Furthermore, to address concerns related to potential immortal time bias, we performed additional sensitivity analyses, varying the time window for tirzepatide initiation to assess whether different initiation periods influenced the results, and by resetting the index date to the HFpEF diagnosis date for both groups
Beyond thirst-related concerns, tirzepatide is associated with several other side effects that patients should recognize
Those who continued GLP-1 treatment for two or two-and-a-half years before discontinuing for the remainder of the study also gained significant risk reduction (7% and 15%, respectively)
But the reconstituted solution should not be used beyond 28 days