does semaglutide keep you awake and Insomnia: What the Evidence Shows How Long Does It Take

Jaclyn Leong, Medical Director of the UCI Health Weight Management Program, at the ObesityHelp 2025 National Conference, where she discussed evidence-based nutrition, resistance training, and integrative strategies to support lean body mass during GLP-1 therapy

By the fourth day of training, considered to be a crucial day on which the most improvement in training and neural plasticity occurs (Meighan et al., 2006), the scopolamine group (mean latency to find the pedestal = 102.4 s) and the scopolamine + Hinge Dihexa group (mean latency = 105.2 s) showed no signs of improvement compared to the vehicle control group (mean latency = 43.0 s), the Hinge group (mean latency = 78.3 s) and the scopolamine -Dihexa group (mean latency = 63.0 s)

This applies even within a clinical trial setting and helps build the safety evidence base for investigational medicines

Peptides such as GHRP-2, GHRP-6, Hexarelin, Sermorelin, and Ipamorelin belong to this class

4 Obesity, insulin resistance, metabolic disturbances such as dysglycaemia and dyslipidaemia, and chronic low-grade systemic inflammation are recognized as fundamental drivers of MASLD