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The real-world study looked at medical records rather than results from a controlled clinical trial

The proposed mechanism linking GLP-1 agonists to gallbladder problems primarily involves reduced gallbladder motility and bile stasis

In agreement with this scenario, inhibition of p70S6K1 activity by p70S6K inhibitor, PF4708971, significantly increased the cell sensitivity to IGF-1R inhibition via reducing the cell growth and colony formation (Fig

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10.1038/s41586-019-1238-8 24 CorpuzH