Chronic stress also drives emotional eating, reduces motivation for exercise, and disrupts sleep, creating a cascade of weight-gain-promoting effects
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Kuzminski AM, Giacco EJ, Allen RH, Stabler SP, Lindenbaum J
Indeed metformin showed synergic effects with Sorafenib (a multikinase inhibitor) (Ozdemir Kutbay et al., 2020) in several TC models ( These in vitro studies make metformin desirable for potential repositioning as anti-cancer compounds in the treatment of TC, thus several studies are still ongoing to deeply characterize its effect
OL subpopulation profiles allowed for the stratification of MS samples into 3 types: (1) having OL subpopulations largely similar to that observed in normal appearing white matter, (2) showing an increase in an OL subpopulation with a stressed profile, and (3) indicating a block in OL differentiation 84