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They also quiet the reward system, which is what sparks the urge to eat tasty food even when you're not hungry, making those foods feel less tempting and less distracting

Those with overweight, a BMI of 27 or more, may qualify if they have conditions like diabetes, high cholesterol, or high blood pressure

R.et al (2016)

In an early phase 1 study of healthy obese participants, setmelanotide demonstrated significant weight loss compared to baseline for all treatment groups receiving 0.01 mg/kg/24 h via SC infusion (NCT02431442) (85, 86)