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It is also possible that radical intermediates nonenzymatically produced from hydroperoxy-phospholipids directly react with GSH, leading to the formation of a highly pro-oxidant GS radical

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29,30 Norrin interacts with both the CRD domain of FZD4 and ectodomain ECD of LRP5/6 by simulating the finger-like loop of Wnt (the structure of Wnt interacts with the CRD domain of FZD), thereby activating the Wnt/-catenin signalling pathway

Complement induces podocyte pyroptosis in membranous nephropathy by mediating mitochondrial dysfunction