new fda ruling on tirzepatide Update: December 19th the ruled the tirzepatide shortage was resolved, however is giving a grace period for compounding pharmacies to continuing manufacturing. This grace period is 60 days. On FDA approval for Zepbound (tirzepatide)

The Science Behind Collagen That Works Not all collagen is created equal

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Matsuzaki T, Sasaki K, Tanizaki Y, Hata J, Fujimi K, Matsui Y, et al

Given that the food environments people live in make it difficult to make healthy choices, I believe that this move will only meaningfully benefit the health of all Americans if it is combined with other policy changes

For practical comparison: | Property | Native IGF-1 | IGF-1 DES | IGF-1 LR3 | |---|---|---|---| | Amino acids | 70 | 67 | 83 | | Half-life | ~10 min | ~20-30 min | ~20-30 h | | IGFBP-3 affinity | High | Low | Very low (~1,000x reduced) | | Relative IGF-1R potency | 1x | ~10x | ~2-3x | | Systemic vs