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As of 2026, these are the milestones that ended broad GLP-1 compounding: Tirzepatide Shortage declared resolved on October 2, 2024 , and reaffirmed after a legal challenge on December 19, 2024

Within a substrate-aware framework, clinical surveillance may therefore include periodic assessment of (i) lean mass trajectory, (ii) micronutrient statusparticularly nutrients supporting enzymatic throughput and redox cyclingand (iii) fat-soluble vitamin indices as indirect indicators of bile-dependent absorption integrity

Anyone who suspects they have experienced an adverse reaction to any unlicensed product should report it via the MHRA Yellow Card scheme , available at yellowcard.mhra.gov.uk

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