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Finally, the results of one randomized controlled trial in 601 patients with common forms of retinitis pigmentosa indicated that supplementation with 400 IU/day of synthetic vitamin E (equivalent to 180 mg/day of RRR --tocopherol) modestly but significantly accelerated the loss of retinal function compared to placebo (123)

10.1038/s41467-020-17871-5 5 ChenJ.LiuJ.ZhangY.TianZ.WangK.ZhangY.et al (2018)

Department of Agriculture, Mary Shaw Shorb was assigned work on the bacterial strain Lactobacillus lactis Dorner (LLD), which was used to make yogurt and other cultured dairy products

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however, a recent phase 1 trial (NCT05597241) indicates apimostinel development may be resuming