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doi: 10.1210/jc.2010-0449

Finally, with renewed focus on supply chain integrity, both 503Bs and 503As must maintain robust documentation to demonstrate compliance with DSCSA requirements, prescription validity, and non-duplication with FDA-approved therapies

Increasing attention has been directed toward the concept of a therapeutic window of opportunity, which frames early PsA as a transitional phase characterized by musculoskeletal symptoms such as arthralgia, dactylitis, and subclinical enthesitis in patients with PsO, often preceding clinically evident arthritis (72), reported that GLP-1RA treatment in PsO patients receiving systemic therapy did not significantly alter the subsequent risk of developing PsA

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At the same time, respondents expressed concern about possible risks associated with lower-cost, compounded GLP-1 products often available through alternative programs but not approved by the U.S