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The expression of CA-AMPK in the medial hypothalamus by adenoviruses increased food intake and body weight, whereas the expression of DN-AMPK inhibited them [88]

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Moreover, with the maximum oral dosage plasma levels are lower compared with the maximal subcutaneous dose (oral 20 mg yields plasma levels of ~25 nM, subcutaneous 1 mg yields plasma levels of ~45 nM (33, 34))

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