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Abstract Fibrosis is a public health issue of great concern characterized by the excessive deposition of extracellular matrix, leading to the destruction of parenchymal tissue and organ dysfunction that places a heavy burden on the global healthcare system due to its high incidence, disability, and mortality

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CNS Neurol Disord Drug Targets 21:766773 Lam JR, Schneider JL, Zhao W, Corley DA (2013) Proton pump inhibitor and histamine 2 receptor antagonist use and vitamin B 12 deficiency

Medically reviewed by Alan Lucks | MD , Alan Lucks MDPC Private Practice - New York on January 10th, 2026

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