Osthole attenuated C10:2-induced pulmonary vascular remodeling by downregulating proliferation markers (PCNA, cyclin A, CDK2), modulating apoptosis markers (Caspase-3, Bax, Bcl-2), inhibiting migration-related proteins (MMP2, MMP9, TGF-), and reducing AMPK-1 and ROS overaccumulation as well as HSP47 expression
By reducing excessive glucagon release, GLP-1 agonists decrease hepatic glucose output and improve overall glycemic control
Confirmed at 28 days A follow-up 28-day study (Babula et al., 2024) extended the finding: 5-Amino-1MQ dose-dependently limited body weight and fat mass gain without changing food intake, and it improved liver markers in obese mice
The finding that lipotoxicity alters incretin receptor expression is reminiscent of the decrease in insulin gene expression observed under similar conditions
Maternal age, ethnicity, stress, alcohol and illicit drug usage, education, body mass index (BMI), fever during pregnancy, and other covariates were controlled during the study
