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The effects of liraglutide and dapagliflozin on cardiac function and structure in a multi-hit mouse model of heart failure with preserved ejection fraction

[PubMed] [Google Scholar] Aja S, Landree LE, Kleman AM, Medghalchi SM, Vadlamudi A, McFadden JM, Aplasca A, Hyun J, Plummer E, Daniels K, Kemm M, Townsend CA, Thupari JN, Kuhajda FP, Moran TH, Ronnett GV

Discontinuation rates due to GI intolerance were 3-7% across doses, comparable to tirzepatide

Most other GLP-1 RAs are used to treat type 2 diabetes mellitus (T2DM)

While it is perhaps somewhat surprising that no group differences in metabolite concentrations were found, either for GABA (as has been shown before) or for GSH, we note that autism is an extremely heterogeneous condition, and that group differences, if present, may be small and relatively uninformative in understanding the broader autism phenotype(Loth et al., 2021)