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Note also that GSH inhibits both GCL and GS, so it is not clear by inspection of the diagram what the effect of raising the activities of GCL and GPX will be

doi: 10.1097/HEP.0000000000000025 53 MorescoMARaccostaLCornaGMaggioniDSonciniMBicciatoSet al

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Patients with active malignancy, pituitary pathology, or uncontrolled diabetes represent populations requiring particularly careful clinical judgment