It was approved in the UK in 2023 for weight management in adults with: BMI 30 kg/m (obesity), or BMI 27 kg/m (overweight) with at least one weight-related condition The medication works in several ways: Reduces hunger signals by acting on the brains appetite control centre Slows stomach emptying , creating longer-lasting fullness after meals Reduces food cravings , particularly for ultra-processed foods Clinical trials show that people taking Wegovy lose an average of 15% of their body weight after 68 weeks, compared to 2.4% with placebo
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All eight reported studies have demonstrated the noninferiority of GLP-1RAs compared to placebo regarding MACE
Factors That Influence Weight Loss on GLP-1 Alone Individual response to GLP-1 therapy depends on multiple variables beyond exercise: baseline metabolism, insulin sensitivity, gastrointestinal tolerance, medication adherence, dietary quality, sleep patterns, and genetic predisposition in peptide-related pathways
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